Chuanzhen Yang 杨传真, Ph.D.

Associate Director

2023.07 - Present     Research Associate Professor at Westlake Laboratory, Hangzhou, China

2018.08 – 2023.06    Lecturer, Capital Medical University, Beijing, China

2013.9 – 2018.07     PhD, Peking University, Beijing, China

2009.9 – 2013.7      Undergraduate, Minzu University of China, Beijing, China

Previous publications by Dr. Chuanzhen Yang, Co-Director of Westlake Meta4D Lab:

1. Chuanzhen Yang^#,Yiliang Zhao#, Liao Wang#, Zihao Guo, Lingdi Ma, Ronghui Yang, Ying Wu, Xuexue Li, Jing Niu, Qiaoyun Chu, Yanxia Fu and Binghui Li*. De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defense. Nat Cell Biol, 2023, 25(6):836-847. (#co-first author)

2. Ronghui Yang^#, Chuanzhen Yang^#, Lingdi Ma, Yiliang Zhao, Zihao Guo, Jing Niu, Qiaoyun Chu, Yingmin Ma, Binghui Li*. Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress. Nat Commun, 2022, 13(1): 7031. (#co-first author)

3. Miao Liu^#, Yuanyuan Wang^#, Chuanzhen Yang^#, Yuxia Ruan^#, Changsen Bai, Qiaoyun Chu, Yanfen Cui, Ceshi Chen, Guoguang Ying, Binghui Li*. Inhibiting both proline biosynthesis and lipogenesis synergistically suppress tumor growth. J Exp Med, 2020, 217(3). (#co-first author)

4. Chuanzhen Yang, Weicheng Zang, Zefang Tang, Yapeng Ji, Ruidan Xu, Aiping Luo, Bin Hu, Zemin Zhang, Zhihua Liu, Xiaofeng Zheng*. A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy. Cancer Res, 2018, 78(4): 1069-1082

5. Chuanzhen Yang ^#, Weicheng Zang^#, Yapeng Ji, Tingting Li，Yongfeng Yang， Xiaofeng Zheng*. Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly (ADP-ribose) polymerase-dependent manner and regulates the DNA damage response. J Biol Chem, 2019, 294(8): 2827-2838. (#co-first author)

6. Ronghui Yang, Zihao Guo, Yiliang Zhao, Lingdi Ma, Binghui Li, Chuanzhen Yang*. Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase. Cell Death Discov, 2021, 7(1):204.（*corresponding author）

7. Liao Wang^#, Yinghui Sun^#, Xijie Liu, Hongjuan Li, Chang Lu, Ronghui Yang, Chuanzhen Yang*, Binghui Li*. SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation. Cancer Biol Med, 2021,19(7):995-1007. （*co-corresponding author）

8. Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, Hongwei Yao, Xi Zhu, Zemin Zhang, Jiafu Ji, Xiaofeng Zheng*. Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nat Commun, 2017, 8: 15308.

9. Weicheng Zang, Chuanzhen Yang, Tingting Li, Liming Liao, Xiaofeng Zheng*. Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Proc Natl Acad Sci U S A, 2019, 116(51): 25624-25633.

10. Yongfeng Yang, Chuanzhen Yang, Tingting Li, Shuyu Yu, Tingting Gan, Jiazhi Hu, Jun Cui and Xiaofeng Zheng*. The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults. Cancer Res, 2020,80(4):719-731.

11. Yuanyuan Wang^#, Changsen Bai^#, Yuxia Ruan^#, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang, Binghui Li*. Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia. Nat Commun, 2019, 10(1): 201.

12. Qiaoyun Chu^#, Jing An^#, Ping Liu, Yihan Song, Xuewei Zhai, Ronghui Yang, Jing Niu, Chuanzhen Yang, Binghui Li*. Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition. J Exp Med, 2023, 220(3): e20221316.

13. Qiaoyun Chu^#, Ping Liu^#, Yihan Song^#, Ronghui Yang^#, Jing An, Xuewei Zhai, Jing Niu, Chuanzhen Yang, Binghui Li*. Stearate-derived very long-chain fatty acids are indispensable to tumor growth. EMBO J, 2023. 42(2): e111268.

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