Research at Westlake Meta4D Lab will focus on these key biological and biomedical questions:
Cell biology and Biochemistry
To address how are different types of lipids and metabolites distributed and organized on cellular membranes, organelles and compartments
To improve our understanding on the organization principles of metabolic pathway components in the cell
Development and physiology
To provide a comprehensive map for the abundances of metabolites and activities of metabolic pathways at different stages of mammalian development
To identify cell-type- and cell-state-specific metabolites, lipids and metabolic pathways and inspire mechanistic studies on metabolic regulation
Aging and Pathology: with a focus on cancer and metabolic diseases
To systematically identify metabolic pathways that are altered during aging
Identify metabolic pathways underlying the progression of metabolic diseases and organ degeneration and acute damage
To identify metabolic pathways associated with tumor progression and therapeutic responses
We are also interested in developing and advancing the following technologies:
Metabolite labeling and tracing in vitro and in vivo
Photochemical Activation of Lipid peroxidation (PALP) for polyunsaturated lipid detection
Click chemistry-based metabolite/lipid labeling
High spatial-temporal resolution imaging of metabolites in live cells
Dynamic metabolomic and lipidomic profiling in situ
MALDI Imaging
DESI Imaging
Artificial Intelligence-empowered imaging data analysis and integration
Clinically compatible metabolic profiling technologies
Lipidomics and metabolomics at single-cell resolution
Metabolic flux analysis in vitro and in vivo
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